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51 CD8+ TRM cells can restrict the entry of Mtb into lung tissue by killing contaminated macrophages, and bring about protecting innate and adaptive immune responses by secreting IFN-γ, TNF-α, and IL-2. When these cytokines are blocked, this protective immune responses disappear entirely.14,fifty two Even though ID BCG vaccination might also ind

[55] Mycobacteria have an outer membrane lipid bilayer.[56] If a Gram stain is carried out, MTB both stains quite weakly "Gram-good" or will not retain dye because of the higher lipid and mycolic acid material of its mobile wall.[57] MTB can stand up to weak disinfectants and endure inside of a dry point out for months. In nature, the bacterium can